Stephen Hawking, who has died aged 76, was Britain's most famous modern day scientist, a genius who dedicated his life to unlocking the secrets of the Universe.
Born on January 8, 1942 - 300 years to the day after the death of the father of modern science, Galileo Galilei - he believed science was his destiny. But fate also dealt Hawking a cruel hand. Most of his life was spent in a wheelchair crippled by amyotrophic lateral sclerosis (ALS), a form of motor neurone disease that attacks the nerves controlling voluntary movement.
Remarkably, Hawking defied predictions he would only live for a few years, overcoming its debilitating effects on his mobility and speech that left him paralysed and able to communicate only via a computer speech synthesiser.
Click through the photos to read 11 great quotes from Stephen Hawking.